Gallery
See the technology in action.
PET Mesh Protective Layer
Patch Surface
Nanofiber Membrane Separation
Adhesive-Free Nanofiber TDDS Platform — Concept Overview
EPIO INC. has developed a patented adhesive-free nanofiber TDDS platform — delivering active ingredients through the skin with precision, without the skin irritation of conventional patches.
Contact UsEvery adhesive-based patch faces the same trade-off — and no one has solved it. Until now.
Chemical adhesives cause contact dermatitis, redness, and chronic itching in over 40% of transdermal patch users — the leading cause of early discontinuation.
Up to 70% of active ingredients remain trapped in the adhesive matrix, leading to imprecise dosing and significant waste of expensive compounds.
Non-porous structures prevent skin respiration, causing sweat accumulation, maceration, and patch detachment — especially during long-wear applications.
Ultra-fine nanofibers (1/1,000 of a hair's width) physically interlock with the skin's micro-contours — no glue required.
Physical micro-interlocking via nanofiber structure provides secure, non-invasive adhesion — eliminating all adhesive-induced irritation.
Rapid onset (Cmax) + sustained 24H plateau — combining immediate therapeutic effect with long-term dose maintenance in one patch.
PES membrane base adaptable to alternative polymers. Applicable to both water-soluble and lipid-soluble active ingredients.
Precise active ingredient loading controlled by nanofiber thickness — without increasing patch size or area.
SEM analytical data (V1.2, May 2026) — PES nanofiber membrane.
40 g/m² · 150 μm — Structural base, provides mechanical support
7 g/m² · 15 μm — Active ingredient loading & precision release core
60 g/m² · 250 μm — Protection & structural integrity
From nicotine cessation to wellness and pharmaceutical delivery — the EPIO platform is designed to scale across categories.
48mg nicotine prototype developed and validated. Zero leakage, zero structural collapse. Designed for smoking cessation programs with improved compliance and reduced skin irritation.
Prototype ReadyLavender aromatherapy patch prototype validated. Platform expandability confirmed for relaxation, focus, and stress relief applications — the growing optimized self market.
Prototype ReadyPlatform adaptable for OTC and ETC pharmaceutical applications — including Alzheimer's, chronic pain, and hormone therapy patches — where skin-friendly long-wear is critical.
In DevelopmentEPIO operates as an IP holder and platform technology supplier — providing nanofiber TDDS solutions to pharmaceutical, biotech, and consumer wellness brands globally.
Open for PartnershipWe are actively seeking development partners, licensees, and co-development collaborators across nicotine, wellness, and pharmaceutical applications.
epio.nano@gmail.com →